South Africa is one of the biodiversity hotspots for Aloe in Africa. This makes it important to evaluate the conservation status and threats to this genus. The South African National Biodiversity Institute (SANBI) Red List was employed to evaluate these two factors. Results revealed that 44% of all species in this genus are of conservation concern with the majority of them facing threats. This study recommends that more attention such as strengthening the protection of these species and controlling the threats identified in this study should be given to species in this genus in terms of conservation management to reduce their risk of extinction.